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FUNCTIONAL MATERIALS
Ultra-high absorption formulation: curcuRouge®
Curcumin is excreted in vivo with little or no absorption. Through technological development, Therabiopharma has dramatically improved the absorption rate of curcumin in the body. Curcumin is originally yellow in color, but this technology has changed it to red by improving the absorption rate.
(Revolutionarily improved curcumin absorption)
An issue of Curcumin
Because of its large, hard crystalline structure, 99% of ordinary curcumin particles are expelled from the body. curcuRouge® breaks up the crystalline structure, allowing it to easily enter the surface cells of the intestinal tract and be absorbed into the body.
solution
curcuRouge® 's highly absorbent technology
Comparison of solubility of curcumin and various curcumins in water
1.synthesized crucumin 2.curcumin supplier（A and B）3.Theracurmin
In vivo comparison among synthesized curcumin, Theracurmin and curcuRouge® ( absorbent comparison in animals)
High-speed passage through the blood-brain barrier of curcuRouge®
Fast penetration into the brain through BBB
curcuRouge® formulation
(10mg / kg oral dose for rats, in vivo)
Clinical trial plan (2020-)
(All randomized, double-blind, group-to-group study)
□Bioavailability (Rat, Healthy Volunteers)
: Completed
Journal title
Journal of Functional Foods 81 (2021) 104443
Title
A novel amorphous preparation improved curcumin bioavailability in healthy volunteers: A single-dose,
double-blind, two-way crossover study
JP
新しい非晶質製剤は健康ボランティアにおけるクルクミンの生物学的利用能を改善した：
健常人ボランティアにおける単回投与二重盲検二方向クロスオーバー試験
□Immunity enhancement effect
(20 cases × 2 groups) :Completed
Journal title
Journal of Nutritional Science and Vitaminology, 67, 249-252,2021
Title
Newly Developed Highly Bioavailable Curcumin Formulation, curcuRougeTM, Reduces Neutrophil/Lymphocyte Ratio in the Elderly: A Double-Blind, Placebo-Controlled Clinical Trial
JP
新開発の高バイオアベイラビリティ型クルクミン製剤curcuRougeTMは高齢者の好中球/リンパ球比を低下させる： 二重盲検プラセボ対照臨床試験
□Knee Osteoarthritis (30 cases × 3 groups)
: Completed
Journal title
Clinical Medicine Insights 04 (03), 415-429 (2023)
Title
Efficacy of High- and Low-Dose, Highly Bioavailable Curcumin (Curcurouge®) for Treating Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Prospective Study
JP
変形性膝関節症に対する高用量および低用量の高生物学的利用能を有するクルクミン（クルクルージュ®）の有効性： 無作為化二重盲検プラセボ対照前向き試験
□COVID-19 Infection (80 cases × 2 groups)
: Completed
Journal title
Journal of Health, Population and Nutrition (2024) 43:93
Title
Efficacy of highly bioavailable oral curcumin in asymptomatic or mild COVID‑19 patients: a double‑blind, randomized, placebo‑controlled Trial
JP
無症状または軽症のCOVID-19患者における高生理活性クルクミン経口投与の有効性：二重盲検無作為化プラセボ対照試験
□Mild Cognitive Impairment (MCI) (30 cases × 2 groups）: Ongoing
□Knee Osteoarthritis (Comparison with hyaluronic acid intra-
articular injection) (50 cases × 2 groups): Ongoing
curcuRouge®capsule Launched in September 2020
Contains 1 capsule of 90 mg of curcumin / 225 mg of curcumin.
62 capsules per product (1 month)
(参考)希望小売価格（税込） 62カプセル入り：￥7,560 124カプセル入り：￥13,600